Our multiscreen research approach is high risk but if successful will have the high reward to establish: 1) how dietary- and microbiota-derived metabolites control brain health and 2) how peroxisome activity affect microbiota-gut-brain axis in patients with NDs such as MS, opening the possibility to identify new disease markers or new targets for therapeutic intervention in these devastating diseases. We will apply biophysical analyses to determine the effects of local and distant metabolites that are produced by peroxisomes on neuronal myelination and inflammation.
The results obtained from the fruit fly study will be verified in cells of the murine brain engineered mimicking human neuropathies and in samples from patients with NDs (e.g. We propose a systems biology (transcriptomics, metabolomics, and proteomics) approach to define the peroxisome-dependent metabolites and genetic networks that control the microbiota-gut-brain axis in health and disease using the fruit fly as a fast and genetically sophisticated model organism. microbiota-nutritional metabolic factors) that controls the brain health. Considering the importance that all the aforementioned factors play in the insurgence and progression of NDs, we believe that the study of peroxisomes in NDs development will shed light on both genetic and environmental factors (e.g. Our team demonstrated that the peroxisome is essential for the metabolic status of the organism, to regulate inflammation during microbial infection and in brain development and to maintain host-commensal interactions. In the last years dysfunction of peroxisomes has been linked to the development of NDs.
Peroxisomes are metabolic organelles that contribute to maintain the healthy metabolic status of the cell. The etiology of these disorders has been associated to multiple and distinct genetic factors but the mechanisms of disease are still unclear.Įmerging evidence suggests that changes in diet and alteration of the microbiota influence the metabolic and inflammatory status of the neurons that is linked to NDs insurgence and progression. Alzheimer’s (AD), Multiple Sclerosis (MS) and Parkinson’s (PD) diseases are examples of neurological disorder that are characterized by progressive problems with movement, or mental functioning that significantly impairs the patients’ daily life. Neurodegenerative diseases (NDs) are incurable debilitating conditions that result in progressive degeneration and/or death of neurons. Nominated Principal Investigator: Di Cara, Francesca Nominated Principal Investigator Affiliation: Dalhousie University Application Title: Healthy brain-how do nutrition and microbiota affect the neurodegeneration? Amount Awarded: $250,000 Co-applicant: Bülow, Margret Hamon, Yannick Savary, Stéphane Research summary By doing so, award recipients strengthen public understanding about and support for interdisciplinary, international, high-risk/high-reward and fast-breaking research.
When NFRF award recipients share their research publicly, they must acknowledge their NFRF funding. Federal support for research is an investment by Canadians.
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